The Biophysical Society of Canada proudly announces Dr. Isaac Li, Canada Research Chair in Single-Molecule Biophysics and Mechanobiology, as the recipient of this year’s Early Career Investigator Award. Dr. Li has made significant contributions in developing single-molecule biophysical methods and mechanobiology, focusing on force-responsive DNA nanostructures, such as molecular force probes.
His innovative research exemplifies creativity and versatility, extending beyond the core area of traditional single-molecule studies. One of his most notable achievements includes developing techniques to explore dynamic biological processes under non-equilibrium conditions, offering new insights into how mechanical forces drive cellular functions.
Dr. Li’s work on transient adhesion bonds in rolling cell adhesion and the design of novel DNA-based probes has opened new avenues for understanding these fundamental biological processes. Recently, their group introduced a live-cell super-resolution force imaging method utilizing Molecular Beacons (MB)-based PAINT. This technique significantly reduces background fluorescence, increases imaging speed, and improves the signal-to-noise ratio, leading to greater precision in imaging cellular tension. Additionally, their team developed the first DNA-based tunable catch-bond that holds exciting potential for new adhesive materials and biomaterials.
With 45 peer-reviewed publications and a strong track record of securing research funding, Dr. Li has made a remarkable impact early in his career. His numerous awards and contributions underline his growing influence in the biophysics community.